Divine Aleru, Microbiome Medicine Research Coordinator

The study provides molecular mechanisms showing how prebiotics like inulin and scFOS directly regulate host immune signaling to modulate inflammation, independent of microbiota changes.

The research focused on short-chain fatty acids (SCFAs), particularly acetate, propionate, and butyrate, and their roles in gastrointestinal and metabolic health. The study examined how SCFAs are produced via microbial fermentation in the gastrointestinal tract and explored their absorption mechanisms, their beneficial effects on gut health, and their therapeutic applications in treating […]

This review explores butyrate’s role in colorectal cancer prevention, showing its potential to modulate epithelial cell behavior and reduce tumor formation. However, the need for optimized delivery methods and further research is emphasized to confirm its efficacy in human CRC prevention.

This paper reviews the potential effects of prebiotics, probiotics, and synbiotics in managing diabetes mellitus (DM), focusing on their ability to restore intestinal barrier function, modulate the immune response, and improve metabolic parameters. It synthesizes findings from various preclinical and clinical studies to assess the effectiveness of these dietary interventions in addressing […]

This review explores the effects of probiotics, prebiotics, and synbiotics on the gut-brain axis, suggesting their potential to enhance cognitive function, emotional regulation, and reduce neuroinflammation, offering promising therapeutic options for neurodegenerative and neuropsychiatric conditions.

This review explores how prebiotics and probiotics modulate the gut microbiome to enhance bone health, improve calcium absorption, and reduce bone loss, suggesting these could be valuable adjuncts to traditional treatments for bone diseases.

This review discusses how prebiotics, such as GOS and inulin, influence gut microbiota and improve depression symptoms through mechanisms like neurotransmitter synthesis and inflammation regulation. The findings are promising but call for more rigorous clinical trials.

This study evaluates the impact of prebiotics, probiotics, and synbiotics on mental health. It found that a high-prebiotic diet improved mood, anxiety, and stress, while probiotics and synbiotics showed minimal effects, highlighting the potential of dietary interventions in mental health management.

This review discusses the potential of probiotics and prebiotics in modulating the gut-brain axis, focusing on their effects on mental disorders like depression and anxiety.

This review highlights the beneficial role of probiotics in managing metabolic diseases like obesity, type 2 diabetes, and hypertension. It explores how probiotics improve gut health, regulate metabolic processes, and reduce inflammation, offering a promising and sustainable approach to treating these conditions.

The review explores the role of prebiotics and probiotics in gut health, highlighting their impact on immunity, metabolic health, and disease prevention. It emphasizes the potential benefits of functional foods enriched with these components, offering a promising avenue for managing chronic health conditions.

This clinical trial demonstrates that prebiotic and probiotic supplementation, in addition to a weight-loss diet, can improve body composition, metabolic parameters, and psychological health in obese individuals, with notable improvements in insulin resistance and muscle strength.

This review explores recent advancements in prebiotic research, highlighting their impact on gut health, immune function, metabolism, and mental well-being. It discusses emerging prebiotics, the development of synbiotics, and innovations in delivery systems like microencapsulation, suggesting a promising future for personalized prebiotic-based therapies.

This review explores the health benefits of prebiotic dietary fibers, highlighting their ability to modulate gut microbiota, enhance immune function, and improve digestive health through fermentation. It examines the regulatory challenges and outlines the promising potential of various prebiotics like FOS, inulin, and GOS in clinical applications.

This review evaluates the therapeutic potential of probiotics, prebiotics, and postbiotics in managing gut-related diseases. It explores their mechanisms, effectiveness in clinical trials, and their future role in personalized medicine to improve gut health and treat conditions such as IBS, obesity, and neuropsychiatric disorders.

This review updates the definition of prebiotics, expanding their scope beyond the gut to include other body sites and highlighting their selective impact on microbiota to confer health benefits.

This review revisits the concept of prebiotics, defining the criteria for classification and highlighting the importance of gut microbiota composition in determining the prebiotic effect. It introduces the prebiotic index as a more accurate measure and underscores the need for further research to optimize prebiotics for health benefits.

Glutathione, the body’s most important intracellular antioxidant, plays a far-reaching role in the immune system that goes beyond simply neutralizing oxidative stress. As a crucial player in nutritional immunity, glutathione helps regulate nutrient competition between the host and pathogens, ensuring that pathogens are deprived of essential nutrients, like cysteine, that are critical for their survival. Through its involvement in redox signaling, cytokine production, and immune cell activation, glutathione contributes to immune resilience, particularly under nutrient-limited conditions.

This review explores the potential of glutathione supplementation in improving antibiotic efficacy and immune responses in HIV-M.tb co-infection, particularly in CNS cases.

This study examines how glutathione influences T cell function in HIV and tuberculosis co-infection. It reveals that restoring GSH levels enhances cytokine production and controls M. tb growth, suggesting therapeutic potential for GSH-based interventions in HIV-infected individuals.

This review examines the crucial role of glutathione in sepsis, emphasizing its function in managing oxidative stress, modulating immune responses, and preventing organ dysfunction. It suggests that glutathione-targeted therapies could offer new opportunities for improving patient outcomes in sepsis.

This review examines how glutathione (GSH) and other thiols regulate bacterial virulence and pathogenesis. It discusses their role in modulating virulence factors, biofilm formation, and host immune interactions, suggesting that targeting GSH pathways could be a novel approach for treating bacterial infections.

This review investigates the role of reactive oxygen species in endometriosis, linking oxidative stress to infertility and pain. It suggests antioxidants as potential therapeutic strategies for disease management.

This review highlights the critical role of metabolic reprogramming in rheumatoid arthritis, where immune cells’ altered metabolism contributes to chronic inflammation and tissue damage, suggesting new therapeutic targets.