Divine Aleru, Microbiome Medicine Research Coordinator

This review explains how the microbiota trains, regulates, and sustains immune function while preventing inflammatory and autoimmune disease.

This review explains how intestinal bacterial biofilms directly modulate mucosal immunity and drive inflammation through structured microbial–host interactions.

This study shows that the antibacterial lectin RegIIIγ maintains a physical barrier between gut microbes and the intestinal lining, preventing immune overactivation.

This review explains how commensal microbiota continuously prime and regulate immune function, shaping tolerance, inflammation control, and pathogen defense.

This review explains how the microbiome controls mucosal immunity by regulating Tregs and Th17 cells and how dysbiosis drives inflammation and disease.

This review explains how the gut microbiome actively shapes immune development, antimicrobial defense, and inflammatory balance through microbial signals and metabolites.

This study shows that gut microbiota–derived propionate induces Reg3 antimicrobial lectins and protects against experimental colitis by promoting epithelial defense and regeneration.

This review explains how microbiota-derived butyrate supports gut barrier function, immune balance, and metabolic health, and why restoring microbial butyrate production is critical for treating gastrointestinal disease.

This review explains how antibiotics disrupt gut microbiota, weaken colonization resistance, and increase infection and disease risk through metabolic and immune mechanisms.

This review explains how gut microbiota prevent bacterial enteric infections through metabolic competition, antimicrobial activity, barrier support, and ecosystem stability.

This review explains how antibiotic disruption of gut microbiota removes colonization resistance, enabling Clostridium difficile infection through metabolic, immune, and ecological mechanisms.

This paper reviewed the emerging role of commensal bacteria in protecting the host against respiratory pathogens, with a strong focus on immune-mediated and direct microbial mechanisms operating along the gut–lung axis. The authors synthesized experimental, translational, and limited human clinical evidence to explain how resident microbiota in the gut, oral cavity, nasal […]

This review explains how the microbiome trains and regulates the immune system, showing how disrupted immune–microbial balance contributes to inflammatory, autoimmune, metabolic, and cancer-related diseases.

This review explains how antimicrobial peptides protect against infection, regulate immunity, and interact with the microbiome, highlighting their promise and limits as clinical therapeutics.

This review explains how moisturizers and emollients restore skin barrier function, reduce inflammation, and limit microbial overgrowth in atopic dermatitis.

This review explains how mucosal immunity relies on constant interaction with the microbiome, showing how commensal microbes shape immune tolerance, barrier integrity, and protection against infection and inflammatory disease.

This review explains how the skin microbiome shapes barrier function, immune responses, and disease risk, highlighting key microbial associations that protect against infection and drive inflammatory skin disorders when disrupted.

This review explains how gut microbes prevent Clostridioides difficile infection through bile acid metabolism, short-chain fatty acids, nutrient competition, and direct antagonism, highlighting microbial functions that protect the gut after antibiotic disruption.

Prebiotics are non-digestible fibers that selectively promote the growth of beneficial gut bacteria, offering a range of health benefits from improved digestion and immune function to enhanced metabolic health. Prebiotics are an essential part of a healthy diet that supports both gut and overall well-being.

This review analyzes the effects of probiotics, prebiotics, and synbiotics on human health, focusing on their impact on the gut-brain axis and various health conditions.

A review exploring the relationship between fiber intake and mental health reveals promising results but highlights the need for further well-designed studies to establish conclusive therapeutic guidelines.

This review analyzes the role of fiber intake in managing depression and anxiety, focusing on prebiotic-rich foods. It finds moderate benefits, especially in anxiety reduction, but calls for further research to confirm these effects in clinical settings.

This study aimed to investigate the effects of inulin supplementation on cognitive flexibility, body composition, and gut microbiota in a mouse model fed a high-fat (HF) diet. Specifically, the study evaluated how inulin modulates cognitive performance and its potential impact on the gut microbiota composition. Who was studied? Male CD1 mice were […]

This paper updates the definitions of prebiotics and prebiotic effects, proposing changes that reflect scientific advancements in microbiome research and regulatory needs.