Divine Aleru, Microbiome Medicine Research Coordinator

This review explores the role of glutathione in chronic illness development, highlighting its function in oxidative stress defense and mitochondrial health. It discusses the potential for GSH augmentation using NAC to improve outcomes in conditions such as metabolic syndrome, cardiovascular disease, and neurodegenerative disorders.

This review highlights glutathione’s key role in protecting plants from metal-induced oxidative stress, focusing on its functions in metal chelation, antioxidative defense, and signaling. GSH’s involvement in metal homeostasis and its regulation of cellular responses to metal stress suggest potential strategies for enhancing plant resilience and improving phytoremediation.

This study examined the protective effect of glutathione (GSH) against oxidative stress-induced cytotoxicity in RAW 264.7 macrophage cells, with a focus on its role in mitigating DNA damage, apoptosis, and mitochondrial dysfunction caused by hydrogen peroxide (H2O2). The researchers investigated how glutathione activates the Nrf2/HO-1 signaling pathway to protect cells from oxidative […]

This study explores the role of glutathione in Streptococcus suis’s resistance to oxidative stress and its contribution to virulence. Deletion of the gshAB and gshT genes significantly impairs oxidative stress tolerance, growth, and virulence, suggesting glutathione as a potential target for therapeutic intervention.

This review explores the critical roles of amino acids in regulating immune cell metabolism and function, emphasizing their potential for modulating immune responses in cancer, infections, and autoimmune diseases. Targeting amino acid metabolism could offer new therapeutic opportunities, but more research is needed to understand these complex mechanisms.

This review analyzes methods for boosting glutathione (GSH) levels, including supplementation, Nrf2 activation, cysteine prodrugs like NACET, and dietary approaches. While promising, further clinical research is needed to confirm their efficacy for treating oxidative stress-related diseases.

This review connects immune-stressing mechanisms, like glucose limitation, oxygen deprivation, and ROS production, to pathogen control during infection. It highlights how the immune system exploits metabolic stress to restrict pathogen growth, offering insights into new therapeutic strategies targeting immune metabolism.

This study shows that glutathione preserves regulatory T cell function by limiting serine metabolism, preventing mTOR overactivation, and maintaining FoxP3 expression.

This review shows that glutathione depletion drives immune dysfunction in HIV by disrupting T-cell balance, gut immunity, and pathogen control, while supplementation restores immune signaling and reduces inflammation.

This review shows that glutathione restores immune balance, limits oxidative stress, and improves host defense against Mycobacterium tuberculosis infection.

This review links oxidative stress, ferroptosis, immune activation, pain, and emerging gut microbiome changes to endometriosis progression and severity.

This study shows that glutathione depletion in hepatic tuberculosis increases oxidative stress, disrupts immune signaling, damages granulomas, and promotes Mycobacterium tuberculosis survival.

This review explains how glutathione deficiency worsens immune dysfunction, oxidative stress, and inflammation during severe COVID-19 and highlights its role in disease severity.

This study shows that glutathione enhances M1-like macrophage activation while controlling oxidative stress through Nrf2-HO-1 signaling, supporting balanced immune defense.

This review explains how macrophage activation, metabolism, and signaling control immune responses in infection, inflammation, and cancer.

This review explains how neutrophils generate reactive oxygen species through NADPH oxidase and how bacteria resist oxidative killing, with clinical relevance for infection susceptibility and inflammation.

This review explains how reactive oxygen species regulate innate immune signaling through controlled protein oxidation, shaping macrophage and neutrophil function in inflammation and disease.

This original research studied how endogenous glutathione (GSH) shapes innate immune signaling in macrophages beyond its antioxidant role. The authors tested whether severe intracellular GSH depletion changes inflammatory gene expression or instead redirects signaling toward antiviral pathways. They focused on toll-like receptor 4 activation using lipopolysaccharide and examined transcriptional responses, redox status, […]

This review explains natural-compounds-glutathione control by polyphenols, terpenoids, and glucosinolates. It shows how these compounds can raise or deplete GSH, shift NRF2-ARE signaling, change GSH enzymes, and alter cancer stress responses in a dose- and context-dependent way.

This review covered glutathione homeostasis by explaining how it protects cells from reactive oxygen species, reactive nitrogen species, and electrophiles, and by mapping the main control points that set GSH levels in tissues. The author described GSH structure as a tripeptide with a reactive cysteine thiol and an unusual γ-glutamyl bond that […]

This review explains glutathione synthesis regulation through cysteine supply, GCL/GS control, and transcriptional networks that include Nrf2, AP-1, and NFκB. It links disease states such as cholestasis, endotoxemia, fibrosis, diabetes, and alcoholism to reduced enzyme expression and depleted GSH.

This review explains glutathione-related enzymes inflammation by detailing how glutathione-dependent enzymes regulate redox balance, detoxification, and inflammatory signaling across tissues exposed to oxidative stress.

This review explains how glutathione-and-microbiome-inflammation fits into redox control, immune sensing, and chronic inflammation. It links GSH depletion with lung disease, atherosclerosis, and severe COVID-19 through ROS, cytokines, NF-κB, and Nrf2 pathways.

Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract that can cause a wide range of symptoms, including abdominal pain, diarrhea, and fatigue. The exact cause of the disease remains unclear, but it is believed to result from a combination of genetic predisposition and environmental factors. Although there is no cure, ongoing advancements in medical research continue to improve management strategies and quality of life for those affected by Crohn’s disease.