Karen Pendergrass, Standards Team

The study investigated the antimicrobial effects of essential oils derived from the Colombian plant Lippia origanoides, specifically focusing on two terpenes, thymol and carvacrol, against polymicrobial biofilms of Streptococcus mutans, Lactobacillus rhamnosus, and Candida albicans. The study also assessed the cytotoxic effects of these compounds on human skin keratinocytes (HaCaT) and periodontal […]

Iron overload in endometriosis contributes to oxidative stress, inflammation, and tissue damage, driving lesion persistence and subfertility. Ferroptosis resistance and dysregulated iron metabolism highlight therapeutic opportunities using iron chelators and modulators.

This study revealed novel molecular signatures linking gut microbiota and transcriptome in Hashimoto’s thyroiditis, advancing diagnostic and therapeutic approaches.

The study investigated the impact of heavy metal exposure on the composition and function of gut microbiota. Specifically, it looked at how heavy metals such as arsenic, cadmium, lead, and mercury affect the diversity, richness, and metabolism of gut bacteria. Who was studied? The research encompassed various model organisms, including humans, […]

The study investigated the relationship between inflammatory markers (IL-6, IL-10, IL-13, and TNF-α), the composition of bacterial flora in peritoneal fluid, and infertility in patients with endometriosis. Who was studied? The participants included 55 patients diagnosed with endometriosis and infertility (observation group) attending a Gynecology Clinic from June 2014 to July […]

The study focused on evaluating the antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of the marine algae Padina pavonica L. Who was studied? The subjects of the study were various microorganisms including Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Streptococcus […]

This study identifies stool-based biomarkers for endometriosis diagnosis and highlights the therapeutic potential of 4-hydroxyindole, a microbiota-derived metabolite, in reducing inflammation and lesion progression.

This review explores how dietary modifications impact endometriosis progression. Antioxidants, omega-3s, and anti-inflammatory diets show promise in symptom relief and hormonal regulation. Personalized nutrition emerges as a pivotal tool for improving patient outcomes.

The study examined the role of biofilms in chronic infections and evaluated whether current medical approaches are effectively targeting biofilm-related infections. Who was studied? The study focused on clinical observations and laboratory analyses involving patients with chronic infections. It analyzed biofilm samples and treatment outcomes in these patients. What were […]

Hyperglycemia weakens placental immunity in GDM, increasing bacterial invasiveness. Metformin reduces bacterial counts of E. coli and S. agalactiae, providing protective benefits beyond insulin. Cytokine tolerization under hyperglycemia highlights the need for enhanced therapeutic interventions.

This review explores the toxicity of heavy metals and pesticides in agricultural ecosystems, detailing their ecological and health impacts. It highlights pathways, bioaccumulation, and synergistic interactions, emphasizing the need for improved agricultural practices and bioremediation to mitigate these toxicants’ harmful effects on soil, plants, and human health.

This review explores the gut-heart axis, highlighting how gut microbiota alterations and metabolites like TMAO and SCFAs contribute to heart failure (HF). It evaluates the gut hypothesis, emphasizing bacterial translocation and inflammation in HF, and discusses potential interventions.

This study explored the gut microbiota of children diagnosed with early-onset pediatric multiple sclerosis (MS) and compared it to controls of similar age and sex. The researchers aimed to identify gut microbial community differences, including taxonomic and functional perturbations, and examined the influence of immunomodulatory drug (IMD) exposure. This study also predicted […]

This study reveals distinct gut microbiota profiles in breast cancer and DCIS patients, with reduced alpha diversity and functional shifts linked to inflammation. Major microbial associations, including enriched Bacteroides guilds, underscore potential microbiome-targeted interventions. Oral microbiota showed minimal differences, highlighting the gut’s critical role in breast cancer progression.

GS2, a gallium complex, inhibits tumor invasion by targeting MMP-14, with implications for anti-metastatic cancer therapy.

This study explored the potential link between the consumption of fruits and vegetables and the risk of laparoscopically confirmed endometriosis. Using data collected from the Nurses’ Health Study II, the researchers analyzed dietary habits over a 22-year period, investigating whether certain food groups and nutrients influenced the likelihood of developing endometriosis. Who […]

This study links higher dietary zinc intake with increased endometriosis risk among American women, highlighting zinc’s complex role in immune modulation and estrogen-related pathways. Findings emphasize the importance of balanced intake for managing endometriosis risk.

This study confirms a bidirectional causal relationship between Graves’ Disease and the gut microbiome. Key taxa like Deltaproteobacteria elevate GD risk, while others, such as Anaerostipes, are protective. These findings advance our understanding of the thyroid-gut axis and suggest microbiome-targeted interventions for GD.

This study shows that kidney function is the key regulator of TMAO levels, linked to cardiovascular risk. Reno-protective therapies, like GLP-1 receptor agonists, may lower TMAO levels, offering new strategies for managing cardiovascular and kidney health.

The review evaluated the evidence for clinical effects of various microbiome-targeted interventions (MBTIs) on cardiometabolic traits. The interventions assessed included dietary changes, dietary supplementation, prebiotics, probiotics, synbiotics, and other therapeutic strategies targeting the gut microbiome. The review aimed to understand how these interventions influence cardiometabolic health outcomes and to identify the mechanisms […]

The review focused on the role of epigenetic changes in endometriosis, exploring how these modifications influence the disease’s etiopathogenesis, diagnosis, and therapeutic approaches. It reviewed existing evidence up to June 2009, linking epigenetic aberrations such as DNA methylation and histone modification to endometriosis, and discussed the potential of these aberrations in developing non-surgical […]

The study focused on pulmonary endometriosis, a rare condition characterized by the presence of endometrial tissue in the lungs. It analyzed a series of historical and recent cases, dividing them into two distinct groups based on the characteristics of the lung lesions and their association with pregnancy and endometrial glands. The study […]

The study focused on the pathophysiology, genetic variants, and epigenetic abnormalities underlying endometriosis and adenomyosis. It emphasized the mechanisms through which these conditions develop, the somatic mutations and epigenetic changes in endometrial and adenomyotic tissues, and the clinical implications of these findings. The primary genetic alterations studied include mutations in the […]

The study focused on analyzing the receptive-phase endometrial metabolome profiles among women with infertility and examining their associations with adherence to the Mediterranean Diet (MD). It aimed to identify metabolomic signatures that could influence the intrauterine environment and impact reproductive outcomes. Who was studied?The study involved 45 women of infertile couples, recruited at the […]