Dr. Umar

The study demonstrates that arsenic exposure is independently associated with CKDu in central India, with CKDu and CKD patients showing heavier burdens of cadmium, lead, and chromium than healthy individuals.

Serum zinc levels decreased with worsening diabetic kidney disease, especially with macroalbuminuria, linking zinc deficiency to nutritional decline, sarcopenia, oxidative stress, and potential microbiome shifts influencing disease progression.

This review outlines how hyperuricemia in chronic kidney disease arises from distinct filtration and tubular reabsorption defects, driving inflammation, endothelial dysfunction, and renal decline while highlighting emerging phenotype-guided approaches to therapy.

This study compared heavy metal exposure and kidney function in Korea, revealing expected nephrotoxicity in the general population but paradoxically preserved eGFR in chronically exposed vulnerable communities.

Nickel exposure induces gut microbiome disorder and serum uric acid elevation by disrupting purine-degrading microbes, increasing inflammatory taxa, impairing intestinal metabolism, and elevating serum uric acid in humans and mice.

This study examined chronic exposure to multiple heavy metals and found strong individual and synergistic effects on renal injury biomarkers, revealing metal–metal interactions highly relevant to environmental and microbiome-linked kidney dysfunction.

This case report describes markedly elevated lead, nickel, and bismuth in the peritoneal fluid of a young woman with endometriosis, highlighting dietary and environmental exposure considerations and potential biomarker relevance.

This study examined blood nickel and endometriosis, revealing significantly higher nickel levels in affected Sri Lankan women, supporting a potential metalloestrogenic role.

A study of celiac patients revealed that persistent symptoms during gluten-free eating may stem from nickel allergic contact mucositis. A low-nickel diet significantly improved gastrointestinal and systemic symptoms.

This study links nickel allergy to overweight status in women and shows that a low-nickel diet reduces BMI and waist size while suggesting immunologic and microbiome-related mechanisms.

Study identifying significantly higher zinc and nickel hypersensitivity in IBS patients, suggesting metal-induced immune activation as a contributor to mucosal inflammation and symptom generation.

Urease enables S. aureus to survive acid stress and persist in murine kidneys. Its expression is regulated by CcpA and Agr, and its activity is essential for long-term infection, highlighting a critical microbial adaptation for persistence in acidic microenvironments.

Nickel-dependent enzymes like urease and hydrogenase are essential for pathogen virulence. This review outlines the mechanisms by which pathogens acquire and utilize nickel and explores implications for therapy and microbiome balance.

This study evaluates nickel chelation therapy using DMG against multidrug-resistant Salmonella and Klebsiella. DMG impaired virulence by inhibiting Ni-dependent enzymes, reduced bacterial load in organs, and improved survival in animal models, offering a promising metallomic intervention.

This study demonstrated distinct microbial dysbiosis in breast cancer, highlighting reduced bacterial load, loss of Sphingomonas, enrichment of Methylobacterium, and impaired antibacterial immune signaling in tumor tissue.

This study analyzed breast cancer microbiota using TCGA RNA-seq data, identifying key microbial differences and linking microbes such as H. influenzae and L. fleischmannii to tumor-related gene expression pathways.

This study shows that postmenopausal breast cancer is associated with significant gut microbiome dysbiosis involving pathogenic enrichment, reduced butyrate pathways, and inflammation-related functional shifts.

Gut microbiome composition in early breast cancer predicts prognosis, chemotherapy response, and neurological toxicity. Chemotherapy shifts microbial structure toward beneficial species, while mouse models confirm causal effects of patient-derived microbiota on tumor behavior.

Oral microbiome diversity and composition were strongly associated with breast cancer and non-malignant breast disease in Ghanaian women, with notable cross-body correlations to fecal microbes suggesting systemic microbial involvement.

This study identified significant gut, but not oral, microbial alterations distinguishing breast cancer, DCIS, and healthy women, including reduced diversity, Bacteroides enrichment, and inflammation-related functional pathways.

This study used shotgun metagenomics to compare gut microbiota in pre- and postmenopausal breast cancer patients and controls, showing breast cancer—not menopause—drives modest but consistent dysbiosis involving key taxa and functional pathways.

This study identifies distinct gut microbiota alterations in Hashimoto’s thyroiditis, including shifts in key genera, correlations with autoantibodies, and a high-performing microbial biomarker model, supporting a role for dysbiosis in thyroid autoimmunity.

This study used 16S rRNA sequencing to compare gut microbiomes of Alzheimer’s patients and controls, revealing reduced Bacteroidetes and increased Actinobacteria and Ruminococcaceae, suggesting microbe-driven influences on AD pathology.

This study identifies reduced diversity and distinct microbial shifts in Alzheimer’s disease, linking specific bacterial genera with amyloid and tau biomarkers and supporting a role for gut–brain interactions in AD.