Dr. Umar

In 423 Chinese women, bacterial vaginosis and high-risk HPV infection were identified as risk factors for cervical intraepithelial neoplasia, while condom use was protective. Lactobacillus iners was enriched under HPV infection and Lactobacillus dominance dropped with bacterial vaginosis.

Patients with chronic kidney disease showed reduced fecal microbial richness and enrichment of Desulfovibrio alongside other genera compared to healthy controls.

A pilot 16S rRNA study found gut microbiota differences between infertile and fertile women and tested prebiotic fiber to address dysbiosis before assisted reproduction.

Stage 4-5 CKD patients showed enriched Proteobacteria and Enterobacteriaceae, while healthy controls showed more Bacteroidetes and Clostridia.

Cognitively impaired patients with brain amyloidosis showed higher blood pro-inflammatory cytokine levels alongside altered abundance of pro- and anti-inflammatory gut bacterial taxa.

Women with postpartum depression showed a distinct gut microbiome, with several butyrate-producing genera depleted. Faecalibacterium fell from 19.79 to 9.22 percent (p equals 0.003), and Phascolarctobacterium, Butyricicoccus, and Megasphaera also declined, with some genera correlating with depression severity and sex hormone levels.

Autistic children showed less diverse gut microbiomes and significantly lower abundances of Prevotella, Coprococcus, and unclassified Veillonellaceae than neurotypical peers.

In a pilot of 37 breast cancer patients, HER2-positive tumors were linked to lower gut microbial diversity and lower Firmicutes abundance before chemotherapy.

Combining gut 16S sequencing with blood transcriptomics in coronary artery disease patients, a panel of 20 bacterial and 30 gene biomarkers distinguished patients from controls with AUC 0.92, and depleted short-chain fatty acid producers were linked to reduced interferon signaling.

Found depleted Bifidobacterium longum and increased Faecalibacterium prausnitzii in gut microbiota of young children with autism spectrum disorder.

A ten-strain gut bacterial signature distinguished boys with autism from neurotypical controls with an AUC of 0.947.

Ovarian tumors sorted into immune-enriched and immune-deficient subtypes carried significantly different intratumoral microbiome profiles, and a 32-microbe signature predicted patient survival (C-index 0.727), pointing to a link between tumor-resident bacteria, antitumor immunity, and prognosis.

Found Lactobacillus crispatus fell from 61.0% in healthy women to 28.5 to 41.6% across chlamydia, candidiasis, and bacterial vaginosis, with L. iners rising in its place.

Shotgun metagenomics found gut dysbiosis, more Parabacteroides merdae, Bacteroides fragilis, Escherichia and Shigella, less Faecalibacterium prausnitzii, in women with PCOS, correlating with testosterone and BMI.

A 123-woman South African metaproteomic study found Candida dominating the vaginal mycobiome, with Candida proteins declining and Malassezia and Conidiobolus proteins rising in bacterial vaginosis.

In obese PCOS patients, three months of dietary inulin lowered BMI, WHR, and inflammatory markers while reshifting gut flora toward higher Bifidobacterium and lower Proteobacteria.

Gut genera Lachnospira and Ruminococcus_gnavus best distinguished chronic kidney disease patients from healthy controls, with AUC values above 0.75.

Women with polycystic ovary syndrome in central China showed elevated fecal acetic and propionic acid plus raised serum markers of gut leakiness and inflammation, with Peptostreptococcaceae and the Bacteroidales S24-7 group enriched compared with healthy controls.

Breast cancer patients showed reduced gut microbial diversity and enrichment of Acidaminococcus, Tyzzerella, and Hungatella, each tied to distinct dietary patterns.

Found higher fecal Actinobacteria, Proteobacteria and Bacilli in children with autism spectrum disorder versus healthy controls.

Transplanting gut microbes from CKD patients into mice raised uraemic toxin levels and worsened kidney fibrosis, implicating gut bacteria in disease progression.

Analysis of over 7000 salivary metagenomes found 108 oral microbial species that discriminate autism spectrum disorder from neurotypical siblings and correlate with IQ.

Orlistat reshaped gut microbiota and metabolomics while improving hormone levels, lipid profiles, and estrous cycling in letrozole/high-fat-diet PCOS rats.

Semaglutide outperformed liraglutide for weight loss in PCOS mice, an effect positively linked to increased gut Helicobacter abundance.