Divine Aleru, Microbiome Medicine Research Coordinator

This review synthesized experimental, translational, and clinical evidence describing the biological functions of Akkermansia muciniphila in intestinal-related diseases. The authors evaluated how this mucin-degrading bacterium contributes to intestinal homeostasis, immune regulation, and metabolic balance, with emphasis on mechanistic pathways rather than descriptive abundance alone. The review integrated findings on live bacteria, pasteurized […]

This review examines how Akkermansia muciniphila shapes gut immune signaling to reduce inflammation, obesity, and diabetes risk. Evidence shows that its abundance and derived proteins strengthen the intestinal barrier, suppress pro-inflammatory cytokines, and improve metabolic outcomes across experimental models and early human trials.

This review maps where Akkermansia muciniphila appears across the human gut and beyond, from early infancy to old age. Evidence links higher abundance with stronger mucus-barrier function and better metabolic health, while lower levels track with IBD, appendicitis severity, obesity, and dysglycemia.

Listeria monocytogenes is an opportunistic pathogen capable of surviving in diverse environments, including soil, water, and decaying vegetation. L. monocytogenes has the unique ability to evade the immune system by moving directly from cell to cell within the host. This intracellular lifestyle allows the bacterium to avoid extracellular immune detection, contributing to its ability to cause invasive diseases like meningitis and septicemia, particularly in the elderly and immunocompromised.

This study explores the virulence mechanisms of Listeria monocytogenes, focusing on its surface proteins and iron acquisition systems, shedding light on potential therapeutic interventions and food safety strategies.

This study demonstrates that bacteriophage P100 is a safe and effective biocontrol agent for reducing Listeria monocytogenes in soft cheeses, offering a promising alternative to traditional antimicrobial agents.

This study demonstrates that the FOP bacteriophage cocktail effectively reduces Listeria monocytogenes levels in the gastrointestinal tract, without disturbing the gut microbiota, offering a promising alternative to antibiotics for treating or preventing Listeria infections.

This case report demonstrates the effectiveness of oral sulfamethoxazole in treating Listeria monocytogenes meningitis in a renal transplant patient, offering an alternative treatment approach for those allergic to penicillin.

This study explores copper resistance in Listeria monocytogenes, identifying how the csoR-copA-copZ operon, regulated by CsoR and CopZ, contributes to copper tolerance.

This study examines how Listeria monocytogenes uses two zinc uptake systems (ZurAM and ZinABC) to survive within the host, highlighting their importance for growth and virulence during infection.

This study explores the role of peroxidase enzymes in Listeria monocytogenes pathogenesis, revealing how the bacteria survive oxidative stress and how targeting specific enzymes could offer new therapeutic approaches for treating infections.

This study on Listeria monocytogenes reveals its mechanisms for acquiring iron from host proteins and external siderophores. Understanding these strategies aids in developing new treatments for infections.

This study explores the critical role of iron acquisition systems in Listeria monocytogenes pathogenesis, focusing on Fur-regulated iron transporters and their impact on bacterial survival and virulence.

This study reveals how Listeria monocytogenes uses listeriolysin S (LLS) as a bacteriocin to alter the gut microbiota, aiding in colonization and infection, with implications for therapeutic interventions targeting microbiota modulation.

This study explores how Listeria monocytogenes organizes its surface proteins, specifically InlA and InlH, to adapt to different host environments and promote virulence, shedding light on the dynamic regulation of bacterial surface components during infection.

This study examines the protective effect of passive immunization with anti-ActA and anti-LLO antibodies against Listeria monocytogenes infection, showing how these antibodies reduce bacterial load and enhance survival in infected mice.

This study reveals how Listeria monocytogenes uses listeriolysin O (LLO) to disrupt host cell membranes, aiding in bacterial survival and spread. It highlights the potential for LLO-targeted therapies and biotechnological applications.

This study highlights the critical role of CD147 in facilitating Listeria monocytogenes membrane protrusion formation and cell-to-cell spreading, offering insights into potential therapeutic targets for limiting infection spread.

This study uncovers how Listeria monocytogenes uses listeriolysin O (LLO) to induce host cell entry via membrane perforation, a novel pathogen strategy for invasion.

This study explores how Listeria monocytogenes InlC modulates the host immune response by inhibiting the NF-κB pathway, highlighting its role in immune evasion and infection persistence.

This review explores the role of internalin proteins in Listeria monocytogenes pathogenesis, focusing on their ability to facilitate bacterial invasion, spread, and crossing of key host barriers such as the intestinal, blood-brain, and placental barriers.

This study investigates the role of Listeria monocytogenes internalin A in the interaction with human E-cadherin, essential for invasion across host barriers, including the placenta, highlighting its species specificity and implications for listeriosis pathogenesis.

This study identifies the InlA–E-cadherin interaction as crucial for Listeria monocytogenes invasion of the human placenta, providing insights into mechanisms of fetoplacental listeriosis.

This review explores the survival mechanisms of Listeria monocytogenes in food production environments, focusing on stress resistance, biofilm formation, and its persistence despite sanitation measures.