Divine Aleru, Microbiome Medicine Research Coordinator

Menarche marks the first occurrence of menstruation, signaling a pivotal moment in a young girl’s transition to womanhood. Understanding this process helps to shed light on the hormonal, physical, and emotional changes that accompany puberty. Explore the importance of menarche, factors that influence its timing, and how it shapes women’s health throughout their lives.

This review elucidates the hormonal and physiological mechanisms underpinning female puberty, detailing HPG and HPA axis activation, pubertal milestones, and regulatory factors, and discusses implications for clinical assessment and future microbiome research integration.

This study identifies significant differences in age of menarche between rural and urban Nigerian girls, highlighting the influence of socioeconomic status and residence. Findings have implications for understanding pubertal timing and its potential links to the microbiome and long-term health risks.

A comprehensive review of evidence on the determinants and health implications of ages at menarche and menopause, highlighting their complex, independent origins and the influence of life-course genetic, environmental, and socioeconomic factors. No consistent direct association was found between the timing of menarche and menopause.

This commentary reviews the global neglect of menstrual health education at menarche, highlighting psychosocial and health consequences for girls. It advocates for standardized, early education and support to empower girls and improve reproductive health, with implications for microbiome-related outcomes.

This study explores the factors influencing age at menarche, menstrual knowledge, and hygiene practices among schoolgirls in Sharjah, UAE. It highlights how socioeconomic factors, education, and hygiene practices impact menstrual health outcomes.

This review explores the link between endometriosis and ovarian cancer, focusing on genetic mutations like ARID1A, oxidative stress, and estrogen receptor loss, which contribute to the development of malignancy, particularly in the endometrioid and clear-cell subtypes.

This review explores the molecular pathogenesis of endometriosis-associated ovarian cancer, highlighting key genetic mutations, hormonal imbalances, and microRNA dysregulation that contribute to the disease. It discusses the potential for personalized treatment strategies based on molecular signatures to improve outcomes in affected patients.

This study examines the association between metformin use and survival outcomes in ovarian cancer patients. A significant survival benefit was found in diabetic patients, suggesting metformin may improve ovarian cancer prognosis, although further research is needed for non-diabetic patients.

This review explores the potential of repurposing non-oncological drugs for cancer therapy, highlighting their efficacy in preclinical studies and their mechanisms of action. It emphasizes the benefits of using established drugs to overcome cancer treatment challenges, particularly in overcoming drug resistance and reducing costs.

The review explores the potential of repurposing non-oncological drugs for ovarian cancer treatment, highlighting their ability to improve chemotherapy effectiveness and reduce treatment costs, with promising findings from preclinical studies and clinical trials.

The study explores drug repositioning as a transformative strategy for ovarian cancer (OC) treatment, highlighting the potential of repurposing existing drugs for more effective, accelerated, and cost-efficient therapies. The review focuses on in vitro experiments with various cancer cell lines and preclinical in vivo models to evaluate the efficacy of repurposed drugs, […]

This review explores the role of targeted therapies in ovarian cancer treatment, focusing on the potential of angiogenesis inhibitors, PARP inhibitors, and folate receptor alpha inhibitors. While promising, further clinical trials and personalized approaches are necessary to enhance survival and treatment outcomes.

This review discusses the role of nutritional interventions in improving the nutritional status and clinical outcomes of women with ovarian cancer during treatment. It highlights the importance of personalized nutrition care and the need for more research to establish effective intervention strategies.

Bacterial vaginosis (BV) is caused by an imbalance in the vaginal microbiota, where the typically dominant Lactobacillus species are significantly reduced, leading to an overgrowth of anaerobic and facultative bacteria.

his systematic review highlights the role of metabolomics in ovarian cancer management, identifying key metabolic alterations in lipids and amino acids that could improve diagnosis, prognosis, and treatment strategies. Further validation is needed for clinical application.

This study profiles metabolic dysregulation in ovarian cancer, identifying key metabolites and pathways altered in OC tissues and biofluids. N1,N12-diacetylspermine emerges as a potential biomarker.

Mendelian randomization identified causal links between 9 metabolites and ovarian cancer risk. Some metabolites promote, others protect against OC. These findings suggest potential biomarkers for diagnosis and treatment but require clinical validation.

A two-sample MR of 486 metabolites reports suggestive causal links across OC and histotypes, maps caffeine/arginine/TCA and alpha-linolenic pathways, and surfaces microbially influenced xenobiotics as potential biomarkers; findings require replication before translation.

This review explores how heavy metals, including cadmium, lead, and mercury, contribute to the development of female cancers by mimicking estrogen, inducing oxidative stress, and causing DNA damage. These findings highlight the need for further research to understand the molecular mechanisms involved and develop effective prevention strategies.

This study investigates how sub-chronic exposure to lead, cadmium, and cobalt induces multidrug resistance in ovarian cancer cells, highlighting the role of drug efflux transporters and reduced apoptosis in treatment resistance. These findings underscore the importance of environmental metal exposure in cancer therapy effectiveness.

The study examines the association between urinary concentrations of heavy metals (arsenic, cadmium, mercury, lead) and survival in patients with advanced high-grade serous ovarian cancer. High levels of these metals correlate with worse outcomes, particularly lead, which significantly contributes to survival prognosis.

This study explores the role of lead and cadmium in gynecological malignancies, focusing on their ability to mimic estrogen and induce oxidative stress, contributing to cancer development. It highlights their potential as biomarkers for early detection and treatment.

This study explores how the concentration of heavy metals, particularly zinc and copper, in the blood of ovarian cancer patients correlates with their recurrence-free survival. It highlights the potential of these metals as biomarkers for prognosis and suggests environmental factors play a role in cancer outcomes.