Divine Aleru, Microbiome Medicine Research Coordinator

The review defines progesterone endometrial tumor suppressor mechanisms, links receptor biology to therapy response, and outlines immune and barrier changes with clear microbiome relevance despite no direct taxa reporting.

This review links menopausal hormone therapy and vaginal microbiome care to safer symptom relief, bleeding control, and prevention. It favors transdermal estradiol and physiologic progestogens, and it highlights estriol plus lactobacilli for urogenital symptoms with minimal systemic exposure.

With the growing understanding of the intratumoral microbiota’s influence on cancer progression, the next frontier in cancer therapy is microbiota-targeted interventions. By introducing beneficial microbes or altering existing microbial populations within tumors, therapies can be designed to modulate the immune system, promote tumor suppression, and improve drug efficacy. However, challenges remain in deciphering the complex relationships between microbes, tumor cells, and the immune system, necessitating more refined research methods and standardized approaches to translate these discoveries into clinical practice.

This study demonstrates the potent anticancer effects of a tumor-resident bacterial consortium in both immunocompetent and immunocompromised mice. The consortium induces tumor remission through selective thrombosis, necrosis, and biofilm formation, offering a promising drug-free strategy for cancer therapy with potential applications in treating solid tumors.

The review examines the therapeutic potential of FMT and next-generation microbiome therapies in treating metabolic disorders. It highlights the promising role of FMT in restoring microbial balance and improving conditions like obesity and type 2 diabetes, though challenges remain in optimizing treatment protocols.

This review examines the immunomodulatory effects of probiotics, detailing how they enhance immune functions through interactions with immune cells in the gut. Probiotics help regulate cytokine release, boost IgA production, and support gut health, offering potential therapeutic benefits for immune disorders.

The review discusses the impact of gut microbiota on cancer therapy outcomes, focusing on chemotherapy and immunotherapy. It highlights how microbiota influences drug effectiveness and immune responses, emphasizing the potential of microbiota modulation for personalized treatment approaches.

This review emphasizes how gut microbiota influences cancer chemotherapy efficacy and toxicity. It discusses microbial species, metabolites, and strategies to optimize chemotherapy response, suggesting that microbiota modulation could improve treatment outcomes.

This review explores the dual role of the intratumoral microbiome in cancer, highlighting its impact on immune modulation and its potential as a target for innovative therapeutic strategies, including enhancing immunotherapy efficacy.

This review explores bacteria-based immunotherapy for cancer, highlighting how bacteria and their components modulate immune responses to enhance tumor targeting and therapy outcomes. It also discusses the potential for combining bacteria with traditional therapies like chemotherapy and immune checkpoint inhibitors.

This review explores the complex role of intratumoral microbiota in cancer, emphasizing their influence on immune responses and the potential for microbiome-based therapies in cancer immunotherapy. It discusses how specific microbes affect tumor progression and therapy resistance, offering insights into new treatment strategies.

This review explores the role of metabolism in cancer, highlighting how tumors adapt their metabolism to survive in the tumor microenvironment (TME) and how systemic metabolism influences treatment. It discusses metabolic reprogramming, immune competition, and the potential for targeted therapies to improve cancer treatment outcomes.

This review explores the complex relationship between inflammation and cancer, examining how chronic inflammation drives tumor initiation, progression, and metastasis. It highlights potential therapeutic strategies targeting inflammatory pathways to improve cancer treatment outcomes.

This review examines the role of intratumoral microbiota in cancer progression, immune modulation, and therapy resistance. It highlights microbial species involved in tumor growth and discusses the potential of microbiome-based treatments to improve cancer therapies.

This review investigates the spatial heterogeneity of intratumoral microbiota and its impact on cancer immunotherapy resistance. It highlights how microbial distribution within tumors influences immune responses and treatment efficacy, suggesting new strategies to overcome resistance and improve cancer therapy outcomes.

The review highlights the role of intratumoral microbiota in cancer initiation, progression, and therapy. It discusses the dual effects of these microbiota on immune responses, emphasizing their potential as diagnostic biomarkers and therapeutic targets in cancer treatment.

This review article explores the role of intratumoral microbiota in cancer initiation, progression, and therapeutic responses. It highlights the complex interactions between microbial communities and the tumor microenvironment (TME) in various cancers, including colorectal, breast, pancreatic, and lung cancers. The review investigates how the presence of specific microbes within tumor tissues influences […]

This review explores the role of fungi in cancer progression, highlighting their impact on tumor development and immune responses. It emphasizes the potential for mycobiome-based cancer diagnostics and therapies, though challenges remain in understanding the exact mechanisms at play.

This review examines the role of intratumoral microbiota in colorectal cancer. It highlights how specific microbes influence tumor progression, immune responses, and therapy resistance, suggesting microbiota manipulation as a novel therapeutic approach.

This review explores how the oral microbiota influences cancer pathogenesis, highlighting its role in immune modulation, inflammation, and tumor progression. It emphasizes the potential of oral microbiota manipulation in improving cancer diagnosis and treatment outcomes.

This review explores how intratumoral microbiota influence cancer initiation, progression, and therapy. It highlights their roles in immune modulation, tumor growth, and therapeutic resistance, suggesting microbiome manipulation as a potential therapeutic strategy.

This review discusses how intratumoral microbiota influence cancer progression and therapy. It explores their roles in immune modulation, inflammation, and treatment resistance, and suggests microbiota manipulation as a potential therapeutic strategy for enhancing cancer treatment outcomes.

This review explores the role of intratumoral microbiota in cancer progression and immunity. It discusses how microbiota influence tumor behavior and therapy outcomes, suggesting potential therapeutic strategies and biomarkers for cancer treatment.

This review explores the role of intratumoral microbiota in cancer onset and progression, emphasizing their potential therapeutic applications in improving cancer treatment outcomes and offering new insights into cancer therapy.