Karen Pendergrass, Standards Team

Joseph F. Petrosino’s editorial highlights the microbiome’s pivotal role in precision medicine, emphasizing its potential to advance personalized diagnostics and therapeutic strategies. The integration of microbiome signatures with other ‘omics’ data, such as genomics and metabolomics, offers a comprehensive understanding of disease mechanisms and tailored treatments. Petrosino draws parallels between microbiome signature research and genomics, […]

This review synthesizes key theories on endometriosis pathogenesis, emphasizing immune, hormonal, and epigenetic interactions in its progression.

The study explored the impact of photobiomodulation therapy using different types of light on the major salivary glands and its subsequent effects on caries risk factors in individuals with high risk for dental caries. The therapy modalities tested included polarized polychromatic light, continuous LED light, and pulsed LED light, each aiming to […]

Excess nickel disrupts gut microbiota, promoting dysbiosis and contributing to conditions like obesity and systemic nickel allergy syndrome (SNAS). Probiotics and nickel-restricted diets show promise in mitigating these effects, underscoring the need for further research and clinical intervention.

This review highlights how gluten-free, Mediterranean, and anti-inflammatory diets improve pain perception in endometriosis by reducing inflammation and modulating the gut microbiome. Probiotics and bioactive nutrients such as curcumin enhance therapeutic outcomes.

The review paper provides a comprehensive overview of the gut microbiota-brain axis (GBA) and its role in various neurological disorders. Specifically, the paper examined the intricate bidirectional communication between the gut microbiota (GM) and the central nervous system (CNS), exploring how dysbiosis (an imbalance in the gut microbiota) contributes to the pathogenesis […]

The study reviewed the relationship between the gut microbiota and endometriosis, focusing on how the gut microbiota may influence the pathogenesis, diagnosis, and potential treatment of endometriosis through various mechanisms such as estrogen modulation, immune response, and inflammation. Who was reviewed? The review did not involve specific individuals as subjects of […]

Pathways of communication between the microbiota and the brain.

This review in Frontiers in Cellular and Infection Microbiology examines the vaginal microbiome’s role in health and disease, particularly bacterial vaginosis (BV). It highlights the shift from a Lactobacillus-dominant microbiome in health to a dysbiotic state in BV, linked to increased risk of STIs, PID, and preterm birth. It also discusses current diagnostic and treatment limitations, emphasizing advanced molecular techniques and innovative therapies like probiotics and vaginal microbiota transplantation (VMT) for better management and improved reproductive health outcomes.

This study highlights hyperbaric oxygen therapy’s (HBOT) role in reducing inflammation and NFκB expression in a mouse model of endometriosis. The findings suggest HBOT as a promising non-invasive treatment for managing endometriosis-associated inflammation, targeting hypoxia-induced molecular pathways and offering potential microbiome benefits through reduced inflammatory burden.

Ammonium tetrathiomolybdate (TM) inhibits endometriosis progression in TNFR1-deficient mice by reducing copper and estradiol levels, lesion growth, angiogenesis, and oxidative stress.

This review explores the significant comorbidity between systemic lupus erythematosus (SLE) and endometriosis, emphasizing shared pathological pathways.

This review highlights the bidirectional relationship between endometriosis and the microbiome, showcasing dysbiosis as a key factor in inflammation and estrogen metabolism. Emerging microbiome-targeted therapies hold promise for diagnosis and treatment.

This study evaluated the associations of zinc, copper, and Zn/Cu ratio with cardiometabolic risk factors in Qatari adults, revealing copper’s protective role and Zn/Cu ratio’s adverse implications for metabolic health.

The study investigated the causal relationship between gut microbiota and the risk of erectile dysfunction (ED) using a two-sample Mendelian randomization approach based on genetic data from large GWAS studies. Who was studied? Genetic data were analyzed from 223,805 participants in Europe for ED and 18,340 participants from 24 cohorts for […]

The study focused on the role of somatic stem cells (SSCs), including endometrial stem cells (EnSCs) and bone marrow-derived mesenchymal stem cells (MSCs), in the pathogenesis of endometriosis. This was conducted through a comprehensive literature review, including in vitro experiments and studies on animal models and human tissue analyses. The research examined the […]

A patient with refractory celiac disease type II achieved complete duodenal villi recovery and symptom resolution after fecal microbiota transfer.

This study explored the association between rheumatoid arthritis and heavy metal exposure, identifying a significant deficiency of copper in RA patients. No significant correlations were found for zinc, cobalt, lead, or nickel. The findings suggest that copper deficiency may play a role in RA, warranting further research on trace metals in autoimmune diseases.

The study investigates the role of cholestyramine for refractory iodine-induced hyperthyroidism, showing rapid FT4 reduction in 12 days.

The study showed dramatic, sustained improvements in ASD symptoms in dizygotic female twins through a personalized, multidisciplinary approach targeting modifiable lifestyle and environmental factors, including microbiome-targeted interventions. These included dietary changes, gluten-free and casein-free diets, and supplements like omega-3 fatty acids and probiotics to support gut health and overall wellbeing.

The study aimed to investigate how endometriosis affects the uterine and cervical bacterial communities. Utilizing next-generation amplicon sequencing of the bacterial 16S rRNA gene, the research sought to identify alterations in these microbiomes associated with endometriosis and to determine if specific bacterial taxa within the cervix could help diagnose active endometriosis, potentially […]

This study demonstrates hyperbaric oxygen therapy (HBOT) achieves complete remission of endometriotic lesions in a rat model by reducing hypoxia, inflammation, and TNF-α levels. While HBOT shows potential as a non-invasive therapy for endometriosis, further studies are needed to validate its impact on microbiome modulation.

The radiotracer [111In]In-FnBPA5 accumulated in the mouse uterus, with uptake varying according to the estrous cycle, suggesting an increased abundance of relaxed fibronectin during estrogen-dependent phases.

This study quantified metalloestrogens—cadmium, nickel, and lead—in ectopic endometrial tissue, suggesting their role in endometriosis persistence.