Dr. Umar

Chinese children with autism spectrum disorder had lower gut microbial diversity and a distinct community structure, with reduced abundance of Lachnoclostridium, Tyzzerella, Flavonifractor, and the family Acidaminococcaceae compared with matched neurotypical children.

Children with autism showed altered gut microbial diversity and composition, and constipated ASD children had depleted Sutterella, Prevotella, and Bacteroides linked to dysregulated metabolism.

Constipated children with autism showed lower gut microbial diversity and a distinct microbiota-SCFA profile, with elevated propionate linked to specific symptom measures, versus typically developing children.

Among 135 chronic kidney disease patients, those eating a low-protein high-fiber diet had more short-chain fatty acid-producing bacteria and lower TMAO, IL-18, and MCP-1 than patients eating high-protein low-fiber diets, who instead showed enriched proteolytic Klebsiella.

Among 957 Chinese children with autism and 161 controls, gut microbial diversity was lower in autism, the Bacteroidetes to Firmicutes ratio fell to 0.54 versus 0.89, and genera including Faecalibacterium, Blautia, Parasutterella, and Veillonella were enriched.

A distinct ovarian cancer microbiome was identified, with key taxa depleted in advanced-stage, high-grade disease and enriched in patients with adverse treatment outcomes.

Women with PCOS showed lower gut microbial diversity plus shifted phylum-level composition and altered predicted microbial function compared with healthy controls.

In 77 Chinese children with autism versus 50 healthy peers, gut bacteria were more diverse and altered, with Bacteroides and Faecalibacterium reduced and Collinsella, Dorea, and Lachnoclostridium raised. Three genera classified autism with an area under the curve of 0.94.

Colombian children with autism showed a raised Firmicutes/Bacteroidetes ratio (0.71 vs 0.48) and enrichment of pro-inflammatory genera, while a 12-week anti-inflammatory diet and probiotics remodeled microbe-immune networks despite little change in overall diversity.

Obese women with PCOS had lower gut microbial diversity and 122 differential fecal metabolites, and fecal DHEA sulfate tracked with serum testosterone.

As chronic kidney disease progressed to end-stage renal disease, the gut microbiome became simpler and more dominated by single genera, with the inflammation marker beta-2 microglobulin emerging as the strongest driver of community structure.

A 245-person, 562-sample kidney transplant study found declining gut microbial diversity and short-chain fatty acid producers precede graft rejection, normalizing afterward.

In a rat model of polycystic ovary syndrome, eight weeks of a ketogenic diet lowered luteinizing hormone, androgens, and insulin, and shifted the gut microbiome by adjusting the Firmicutes to Bacteroidetes ratio.

Cognitively impaired patients with brain amyloidosis showed higher blood pro-inflammatory cytokine levels alongside altered abundance of pro- and anti-inflammatory gut bacterial taxa.

Breast cancer patients showed reduced gut microbial diversity and enrichment of Acidaminococcus, Tyzzerella, and Hungatella, each tied to distinct dietary patterns.

Orlistat reshaped gut microbiota and metabolomics while improving hormone levels, lipid profiles, and estrous cycling in letrozole/high-fat-diet PCOS rats.

Semaglutide outperformed liraglutide for weight loss in PCOS mice, an effect positively linked to increased gut Helicobacter abundance.

Ovarian tumors sorted into immune-enriched and immune-deficient subtypes carried significantly different intratumoral microbiome profiles, and a 32-microbe signature predicted patient survival (C-index 0.727), pointing to a link between tumor-resident bacteria, antitumor immunity, and prognosis.

Comparing 159 breast tissue samples, healthy breast tissue showed a distinct bacterial and functional signature. Prediagnostic tissue from women who later developed cancer already carried an intermediate dysbiosis, with reduced microbial metabolic potential, that intensified in tumor and adjacent normal tissue.

In obese PCOS patients, three months of dietary inulin lowered BMI, WHR, and inflammatory markers while reshifting gut flora toward higher Bifidobacterium and lower Proteobacteria.

Women with postpartum depression showed a distinct gut microbiome, with several butyrate-producing genera depleted. Faecalibacterium fell from 19.79 to 9.22 percent (p equals 0.003), and Phascolarctobacterium, Butyricicoccus, and Megasphaera also declined, with some genera correlating with depression severity and sex hormone levels.

A pilot 16S rRNA study found gut microbiota differences between infertile and fertile women and tested prebiotic fiber to address dysbiosis before assisted reproduction.

Women with polycystic ovary syndrome in central China showed elevated fecal acetic and propionic acid plus raised serum markers of gut leakiness and inflammation, with Peptostreptococcaceae and the Bacteroidales S24-7 group enriched compared with healthy controls.

Shotgun metagenomics found gut dysbiosis, more Parabacteroides merdae, Bacteroides fragilis, Escherichia and Shigella, less Faecalibacterium prausnitzii, in women with PCOS, correlating with testosterone and BMI.