Divine Aleru, Microbiome Medicine Research Coordinator

This review identifies impaired sensitivity of GABA-A receptors to the neurosteroid allopregnanolone as central to PMDD, linking receptor plasticity and stress dysregulation to mood symptoms, and highlights promising treatments targeting this pathway.

This study identified specific gut microbiota alterations, including reduced butyrate- and GABA-producing bacteria, associated with premenstrual disorder severity, offering new insights into PMD pathophysiology and potential microbiome-targeted treatments.

Among Ethiopian female university students, PMDD affects nearly two-thirds and links strongly to severe menstrual pain, irregular cycles, low social support, and contraceptive use. Early identification and comprehensive care are essential to alleviate its academic and psychological impacts.

Among Ethiopian high school girls, PMDD affects one-third, linked to irregular cycles, depression, prolonged menstruation, and stress. Early screening and mental health support are crucial to improving well-being and academic success.

Hungarian women with probable PMDD experience high rates of anxio-depressive symptoms and reduced well-being. Retrospective screening suggests higher-than-expected prevalence, highlighting the need for better diagnostic tools and tailored treatment to address this underrecognized disorder.

This paper reviewed the neurological basis of premenstrual dysphoric disorder (PMDD), emphasizing its recognition as a distinct mood disorder linked to menstrual cycle hormonal fluctuations. It summarized advances in brain imaging and neurophysiological studies demonstrating altered brain function in PMDD patients, particularly in prefrontal cortex regions involved in executive function and emotion […]

Women with PMS/PMDD experience disrupted biological rhythms, notably lower melatonin, higher nighttime temperature, and poor sleep quality. These circadian disturbances contribute to symptom severity, suggesting chronobiological targets for improved diagnosis and treatment.

This review delineates PMDD’s unique neurobiology, highlighting hormone sensitivity, GABAergic dysfunction, and stress interaction. SSRIs provide rapid symptom relief, with hormonal and behavioral therapies complementing care. It emphasizes precise diagnosis and individualized, multidisciplinary treatment to improve outcomes in this debilitating disorder.

Premenstrual dysphoric disorder (PMDD) significantly impairs women’s lives due to abnormal sensitivity to hormonal fluctuations. Accurate diagnosis relies on prospective symptom tracking. Evidence supports SSRIs and hormonal treatments as effective management strategies. Emerging therapies and multidisciplinary care models promise improved outcomes for this complex and under-recognized disorder.

Symptom-onset dosing of sertraline effectively reduces PMDD symptoms, especially mood-related ones, with fewer side effects and limited drug exposure. This targeted approach offers a promising, patient-friendly alternative to continuous SSRI treatment for premenstrual dysphoric disorder.

Lactoferrin (LF) is a naturally occurring iron-binding glycoprotein classified as a postbiotic with immunomodulatory, antimicrobial, and prebiotic-like properties.

This meta-analysis identifies a significant association between smoking and increased risk of PMS and PMDD. Women who smoke are more likely to experience these disorders, with stronger effects in PMDD.

This study highlights the significant link between tobacco consumption and the increased risk of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). Women who smoke are at higher odds of developing these disorders, with a dose-response relationship.

This study explores the association between gut microbiota composition and the severity of premenstrual symptoms, suggesting a potential role for microbiome-based therapies in managing PMS.

This review examines the latest insights into the etiology and treatment of Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD), focusing on hormonal and neurosteroid imbalances.

This systematic review and meta-analysis estimate the global prevalence of PMS, revealing wide variations across countries and highlighting the need for standardized diagnostic approaches.

This systematic review and meta-analysis explores the effectiveness of herbal medicine and nutritional supplements in reducing PMS symptoms, highlighting significant reductions in physical, mood, and behavioral symptoms.

This narrative review explores how exercise can help manage the symptoms of Premenstrual Syndrome (PMS), focusing on the physiological and psychological benefits of regular physical activity.

This review explores premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), focusing on symptoms, prevalence, risk factors, and treatment options.

Probiotics are live microorganisms that offer significant health benefits when administered in adequate amounts. They primarily work by modulating the gut microbiome, supporting a balanced microbial ecosystem. Probiotics have been shown to improve gut health, modulate immune responses, and even influence metabolic and mental health disorders. With growing evidence supporting their therapeutic potential, probiotics are increasingly recognized for their role in treating conditions like irritable bowel syndrome (IBS), antibiotic-associated diarrhea (AAD), and even mental health conditions like depression and anxiety through their impact on the gut-brain axis.

Ginger essential oil and citral significantly reduce atherosclerotic plaques, inflammation, and harmful TMAO production by modulating gut microbiota, highlighting their therapeutic potential in managing cardiovascular diseases through dietary intervention.

This review explores how essential oils and nanoparticles modulate gut microbiota, highlighting beneficial effects of oils like d-limonene and risks from nanoparticles such as silver and titanium dioxide. It emphasizes their therapeutic potential and concerns regarding gut microbiome health and systemic inflammatory impacts.

Essential oils from savory, parsley, and rosemary beneficially alter gut microbiota, reduce harmful metabolites like TMAO, enhance beneficial SCFAs, and significantly lower inflammatory and oxidative stress markers, highlighting their potential as nutraceutical interventions for ischemic heart disease and type-2 diabetes mellitus management.

This review explores essential oils as alternative treatments in dentistry, highlighting their efficacy against major oral pathogens. Findings emphasize their antimicrobial, anti-inflammatory, and antifungal properties, supporting their use against oral diseases like periodontitis, dental caries, and oral candidiasis.