Feeding the gut microbiome: impact on multiple sclerosisOriginal paper
Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease, four years before the first published case study.
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This review describes how diet shapes the gut microbiome and the course of multiple sclerosis. It compiles the MS microbiome directions, with Methanobrevibacter, Akkermansia and Desulfovibrionaceae increased and butyrate producers such as Faecalibacterium, Butyricimonas and Clostridium clusters IV and XIVa decreased, and reviews probiotic, prebiotic and postbiotic strategies that target the gut in MS.