Association of intestinal dysbiosis with susceptibility to multiple sclerosis: Evidence from different population studiesOriginal paper
Karen Pendergrass is a microbiome researcher specializing in microbiome-targeted interventions (MBTIs). She systematically analyzes scientific literature to identify microbial patterns, develop hypotheses, and validate interventions. As the founder of the Microbiome Signatures Database, she bridges microbiome research with clinical practice. In 2012, based on her own investigative research, she became the first documented case of FMT for Celiac Disease, four years before the first published case study.
Read MoreWhat was studied?
This review synthesizes population studies linking gut dysbiosis to MS. It highlights depletion of anti-inflammatory commensals (Prevotella, Parabacteroides, Bacteroides) and enrichment of pro-inflammatory taxa (Akkermansia, Dorea, Blautia, Pseudomonas, Bilophila, Methanobrevibacter). It notes that Desulfovibrionaceae sequester cysteine and can lower glutathione, an antioxidant that protects the blood-brain barrier, tying a sulfidogenic shift to oxidative injury in MS.